DNA double-strand break repair through homologous recombination in fibroblasts from a patient with autosomal recessive complete BCL10 deficiency is impaired. Given the relevance of double-strand break repair in the onset of cancer, it is important to highlight that homologous recombination is BCL10-dependent in human fibroblasts.
https://www.ncbi.nlm.nih.gov/pubmed/30660642